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KMID : 0371320080740040248
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Journal of the Korean Surgical Society
2008 Volume.74 No. 4 p.248 ~ p.254
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Phased Reduction of Cyclosporine Combined with Mycophenolate Mofetil in Renal Transplant Recipients: Three-year Results of a Prospective Study
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Kang Jin-Mo
Park Yang-Jin
Ha Jong-Won
Lee Tae-Seung
Chung Jung-Kee
Kim Yon-Su
Ahn Curie
Kim Sang-Joon
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Abstract
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Purpose: Although cyclosporine (CsA) improves short-term renal graft outcomes, many paradigms reduce or withdraw this drug because of its nephrotoxicity. However, inadequate immunosuppression with azathioprine led to little success. We conducted a prospective study to define the prolonged effect of CsA reduction in stable renal transplant recipients with mycophenolate mofetil (MMF).
Methods: Thirty-nine primary renal transplant recipients were divided into two cohorts, the AZA (N=13) and the MMF cohort (N=26). Both cohorts were allowed to reduce the CsA dose up to 50% of baseline within 3 to 4 months of conversion to AZA or MMF. Graft function, clinical parameters, and adverse events were monitored for up to 3 years.
Results: Ccr gradually deteriorated in the AZA cohort, but was stable in the MMF cohort. There was no episode of acute rejection or graft loss observed in either cohort.
Conclusion: The CsA dose can be reduced in combination with MMF treatment in stable renal transplant recipients after 2 years of transplantation, resulting in beneficial effects on Ccr, lipid profiles, and blood pressure. (J Korean Surg Soc 2008;74:248-254)
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KEYWORD
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Cyclosporine reduction, Mycophenolate mofetil, Kidney transplantation
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